National Surveillance of Fungemia in Denmark 2010-11

Ref ID: 18796

Author:

M. C. Arendrup, MD, PhD – Head of Unit, Danish Fungaemia Study Group;

Author address:

Statens Serum Institut, Copenhagen, Denmark.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Significant changes in the management of fungaemia have occurred over the last decade with increased use of fluconazole prophylaxis, of empirical treatment and of echinocandins as first line agents for documented disease. These changes may influence the epidemiology incl susceptibility pattern of fungaemia. A nationwide fungaemia surveillance programme with prospective collection and susceptibility testing of all blood isolates has been active in Denmark since 2010 and the data are presented here in comparison with retrospective data from previous years. Methods: The initial isolate from each fungaemia episode (unique isolates within a 3 week period) was referred to the National Mycology Reference Laboratory for verification of species identification and susceptibility testing (AMB: Etest, other agents: EUCAST EDEF7.2). Population data were obtained from the public databases and individual patient data from the laboratory database systems. Chi-square test was used for comparison of changes. P-values <0.05 (2-tailed) were considered statistically significant. Results: A total of 1,081 isolates from 1,047 episodes of fungemia were recorded in 995 patients. The incidence was significantly higher in 2011 (10.05/100,000) than in 2012 (8.82/100,000). The number of patients, episodes and recovered isolates increased by 13.1%, 14.5% and 14.1%, respectively, and by 10.8%, 11.4% and 11.8% compared to the preceding 6 year period (2004-9). C. albicans accounted for 52.1% but declined 2004-2011 (P 0.0155). C. glabrata accounted for 28% and increased (P <0.0001). C. krusei, C. tropicalis and C. parapsilosis were rare isolates (3.3-4.2%). The incidence and distribution of species varied by age group and by gender. Overall, the resistance rates were as follows: AMB: 2.7%, ANF: 6.2%, FLC: 21.8%, ITR: 12%, 35.8% and VRC: 15.0%. However, the rate varied significantly by species and the majority was due to intrinsic resistance. Conclusions: The incidence of fungaemia continues to increase in Denmark and is associated with a decreasing proportion being susceptible to FLC. Changes in demography (increasing elderly population), a higher age specific incidence among the elderly and changes in antifungal strategies may at least in part explain the changes.

Abstract Number: M-318

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster