Is the incidence of candidaemia caused by Candida glabrata increasing in Brazil? Five-year surveillance of Candida bloodstream infection in a university reference hospital in southeastern Brazil

Ref ID: 17739

Author:

M.L. Moretti, P. Trabasso, L. Lyra, R. Fagnani, M.R. Resende,
L.F. Bachur, L.G.O. Cardoso*, A.Z. Schreiber

Author address:

Campinas, BR)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objective: To determine the epidemiology of Candida bloodstream
infection in a 5-year surveillance.
Methods: From 2006 to 2010, a retrospective study was conducted in
a university referral tertiary care hospital to study the frequency and
distribution of Candida species in different medical specialties. The use
of mechanical ventilation, central venous catheter and urinary catheter
were recorded per 1000 patient-days and the use of antifungal was
calculated using defined daily dose (DDD).
Results: A total of 313 episodes were identified and the overall
incidence was 0.57 (0.43-0.71) episodes per 1000 patients-day. C.
albicans caused 44% of the overall episodes, followed by C. tropicalis
(21.7%), C. parapsilosis (14.4%), C. glabrata (11.2%) and C. krusei
(3.5%). The incidence of C. glabrata significantly increased from 2006
to 2010 (range: 4.3-23.5%) (p = 0.024) and C. parapsilosis decreased
(p = 0.046). C. glabrata was associated with malignancies (p = 0.004)
and C. krusei with hematologic malignancies (p < 0.0001). The use of antifungal was higher in the hematology/bone marrow transplant units and represented 40% of all fluconazole prescription in the hospital. There was no correlation with the use of fluconazole and the increasing ratio of C. glabrata (r = 0.60). The use of invasive devices was significantly higher in the ICUs than the medical and surgical emergencies units (p < 0.001). In contrast, the emergencies had higher incidence of candidemia (2-2.1 episodes/1000 patients-day) than the ICUs (1.6 episodes 1000 patients-day). Conclusion: C. glabrata showed a significant raise differently from the current national literature where C. parapsilosis remained the most

Abstract Number: P783

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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