Is hypereosinophilic asthma a specific phenotype of asthma?

Ref ID: 18408

Author:

Pauline Pradère , Yurdagul Uzunhan, Jacques Cadranel,
Anne Bergeron-Lafaurie, Dominique Israí«l-Biet, Gilles Garcia,
Stéphane Jouveshomme, Muriel Varrin , Michel Aubier, Bruno Crestani,
Camille Taillé.

Author address:

Service de Pneumologie, Hôpital Bichat-Claude Bernard, Paris,
France; Service de Pneumologie, Hôpital Avicennes, Bobigny, France; Service
de Pneumologie, Hôpital Tenon, Paris, France; Service de Pneumologie, Hôpital
Antoine Béclère, Clamart, Franc

Full conference title:

European Respiratory Congress

Abstract:

Introduction: Blood eosinophilia >1000/mm3 in patients with asthma should
evoke particular forms of the disease, especially Churg-Strauss Syndrome (CSS)
and allergic bronchopulmonary aspergillosis (ABPA). Little is known about patients
who do not fulfill criteria for these diseases, usually referred as Hypereosinophilic
Asthma (HA).
Aim of the study: To describe clinical and functional characteristics of patients
with HA and to assess the prevalence of CSS and ABPA in asthma patients with
blood hypereosinophilia.
Methods: Retrospective study of 79 adult asthma patients with blood eosinophils
count >1000/mm3 , compared with a control group of 30 asthma patients without
blood hypereosinophilia (<1000/mm3 ), defined as Non hyperEosinophilic Asthma (NEA) Results: 90% of patients and 100% of controls had severe asthma, according to GINA. Main characteristics of the 4 groups are available on table 1. Conclusion: When compared with the NEA group, HA seems to represent a subgroup of patients, mostly male, characterized by non atopic disease and high prevalence of nasal polyposis. CSS and HA share many similarities, suggesting an overlap between the diseases in some cases.

Abstract Number: 1873

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

New link: NULL

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