Invasive fungal infections in a pediatric oncology ward – Surveillance study over an 8-year period

Ref ID: 18586

Author:

G. Kropshofer (1), R. Crazzolara (1), C. Lass-Flörl (2),
M. Freund (3), A. Klein-Franke (1), B. Meister (1)

Author address:

(1)Hematooncology (Innsbruck, AT); (2)Microbiology (Innsbruck,
AT); (3)Radiodiagnostic (Innsbruck, AT)

Full conference title:

Annual Meeting of the EBMT, 36th

Abstract:

Background: Invasive fungal infections remain an important
complication in hematologic malignancies and stem transplantation (SCT). This retrospective single center study analyzed
the incidence and the outcome of proven fungal infections in
pediatric patients over the past decade.
Methods: Between 2000 and 2008 we evaluated 503 patients
at our institution who underwent treatment with either cytoreductive chemotherapy alone or with subsequent hematopoetic stem cell transplantation. Diagnoses were composed as
follows: leukemia n = 153, solid tumors/lymphomas n = 309,
SAA/MDS: 14, others n = 27
Results: Among 503 children treated in 3 patients (2,6%) a
proven (CT guided percutaneous biopsy respectively post
mortem diagnosis) systemic fungal infection was documented.
Aspergillus spp. w as the predominant fungus (n = 7), followed
by Zygomycetes (n = 3, Candida spp. (n = 2) and one Irpex lacteus. The lung was the organ predominately affected. Other
organs involved were the brain, paranasal sinuses and liver.
3 pts. were clinically cured, 7 pts. died due to relapse of the
underlying disease, 1 due to multiorgan failure and two pts.
died from fungal disease despite therapy.
Conclusion: The incidence of mould infections has increased in
recent years, particulary those due to Aspergillus spp., Fusarium and Zygomycetes. Therefore biopsy of suspected fungal
infections in immunocompromised patients is of paramount
importance and has direct implication on systemic fungal therapy and hopefully outcome.

Abstract Number: P770

Conference Year: 2010

Link to conference website: NULL

New link: NULL

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