Invasive fungal infections during a construction period

Ref ID: 18626

Author:

G. Yilmaz Bozkurt, S. Civriz Bozdag, P. Topcuoglu, A. Azap,
M. Arat, M. Beksac, O. Ilhan, M. Ozcan, O. Arslan, G. Gurman

Author address:

Ankara University School of Medicine (Ankara, TR)

Full conference title:

Annual Meeting of the EBMT, 37th

Abstract:

Fungal infection with an incidence about 15%; remains a major
cause of infectious death in the allogeneic stem cell transplantation. The risk has considered to be lower in the autologus
transplantation. We aimed to fi nd the fungal infection rates during the construction of another building near a transplantation
unit and asess the outcomes of antifungal prophylaxsis.
Sixty four autologus and thirty four allogeneic transplantation
patients were evaluated respectively. In the autologus group,
Female/Male: 23/41, median age was 51 years (36-70). Diagnosis of patients were Non Hodgkin lymphoma/Hodgkin lymphoma/multil myeloma; 11/6/47 respectively. Patients were given
amphotericin deoxycholate ( 0.3 mg/kg) for fi ve months after the
construction and fl uconazole (200 mg ) in the rest 3 months.
In the allogeneic transplantation group Female /Male:15/19
Median age was 30 (19-58)years. Diagnosis of patients were
Acute myeloblastic leukemia/acute lymphoblastic leukemia/
Myelofi brosis/myelodisplastic syndrome/Hodgkin/Aplastic anemia/Paroksismal nocturnal hemoglobinuria: 18/7/2/1/1/2/2/1.
Five patients had unrelated HLA matched peripheral stem cell
transplantation and three patients had unrelated cord blood
transplantation. Six patients were given secondary prophilaxysis with voriconazole. The rest of were given amphotericin
deoxycholate( 0.3 mg/kg) as primary propfi laxysis for 8 months
after the construction.
In the autologus patients group only two (3%) patients were
diagnosed as invasive pulmonary aspergillus infection by computerized tomography; one in the amphotericin group and the
other in the fl uconazole.
In the allogeneic secondary prophilaxysis group, one patient
had progressive fungal infection and died because of bacterial sepsis, respiratory failure. In the primary prophylaxsis group
fi ve patients (17%) diagnosed as invasive fungal infection
during the follow up. Median time from hospitalization to diagnosis were 30 days and median time from transplantation to
diagnosis were 16 days.
We showed that during the construction period amphotericin prophylaxsis must be given to allogeneic transplantation patients but it has no superiority for autologus patients.
It has to be decided by the physician according to patient
characteristics.

Abstract Number: P818

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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