Invasive fungal infection burden at a country level: a population-based analysis over the last decade, France, 2001-2010

Ref ID: 19400

Author:

O. Lortholary,1 D. Bitar,2 Y.Le Strat,2 J. Nicolau,2 B. Coignard,2
P. Tattevin,3 D. Che2 and F. Dromer1

Author address:

1Institut Pasteur, Paris, France; 2InVS, St Maurice, France and
3CHU Pontchaillou, Rennes, France

Full conference title:

6th Trends in Medical Mycology 2013

Date: 11 October 2014

Abstract:

Objectives Trends of invasive fungal infections (IFI) are changing in
relation with at risk populations. Benchmark estimates of the IFI bur-
den at country level are needed to identify priority areas for
improved prevention and control.
Methods The incidence, lethality, trends and risk factors (RF) of the
five most frequent IFIs registered in the French hospital discharge
database, during 2001-2010, were analysed.
Results There were 35,876 incident IFIs including candidemia
(43.3%), Pneumocystis jirovecii pneumonia (Pjp: 26.1%), invasive
aspergillosis (IA: 23.9%), cryptococcosis (5.2%) and mucormycosis
(1.5%). The overall incidence was 5.9 cases/100,000persons/year
and lethality was 27.6%. Annual incidences increased over time for
candidemia, IA and mucormycosis (+7.8%, +4.4%, +7.3%) and
decreased for Pjp and cryptococcosis (8.5% and 9.8%), respec-
tively (P < 0.001). Pjp incidence decreased in AIDS patients (14.3%), but increased together with a higher lethality in seronega- tive cases (+13,3% and +5.6%), respectively (P < 0.001). Candidemia and IA annual incidences increased in patients with hematological malignancies (HM) (+5.8% and +4.3% respectively, P < 0.001). Can- didemia, IA and Pjp annual incidence increased in patients with chronic renal failure (> +10% each, P < 0.001). The risk of death was significantly increased in HM-associated candidemia, IA, muco- rmycosis, and non-AIDS cryptococcosis; in tumors-associated candi- demia, IA, and non-AIDS Pjp; and in cirrhosis-associated candidemia, IA, and non-AIDS Pjp or cryptococcosis. Conclusion IFI now represent a major public health priority in developed countries.

Abstract Number: p118

Conference Year: 2013

Link to conference website: NULL

New link: NULL

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