Inhibitory activity of lactobacilli against human pathogenic fungi belonging to the genus Microsporum and Epidermophyton

Ref ID: 18434


, Sandra Galle
, Elke K. Arendt
, Fiona Maher
Aidan Coffey

Author address:

Cork Institute of Technology, Cork, Ireland;
University College Cork, Cork,

Full conference title:

Society for General Microbiology

Date: 26 March 2014


The aim of this study was to identify antifungal lactic acid bacteria
and characterize their activity against the dermatophyte Microsporum
and Epidermophyton. 220 different lactic acid bacteria were isolated
and initially screened for anti- Aspergillus activity. Four strains,
which exhibited strong inhibitory activity were then tested against
the dermatophytes Microsporum canis, Microsporum gypseum and
Epidermophyton floccosum which they also caused inhibition as observed
by large fungal clearing on agar surface. The strongest inhibition was
seen with Lactobacillus reuteri ee1p. When freeze-dried cell-free
supernatant powder from this strain was incorporated in culture
medium at concentrations greater than 2%, fungal colony growth
was inhibited. Addition of the powder at 5% to liquid cultures caused
complete inhibition of fungal growth on the basis of turbidity. Reuterin
was undetectable in all four antifungal strains. The cell free supernatant
of Lb. reuteri ee1p was run through the HPLC. The spectrum produced
was compared to a standard chromatoGram-of known anti-fungal
compounds to help identify the agents responsible and several
possible candidates were identified.

Abstract Number: CMM/25

Conference Year: 2012

Link to conference website:

New link: NULL

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