Inhalation antigens sensitisation in Czech hypersensitivity pneumonitis patients

Author:

Sterclova M 1; Paulik M 2; Skibova J 3; Vasakova M 4

Author address:

1 Thomayer Hospital and 1st Faculty of Medicine Charles University, Prague, Czech Republic; 2 Thomayer Hospital, Prague, Czech Republic; 3 Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 4 Thomayer Hospital and 1st Medical School Charles University, Prague, Czech Republic

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2017

Date: 20 August 2020

Abstract:

Introduction: Hypersensitivity pneumonitis (HP) develops after repeated exposure to inhalation antigen in susceptible individuals. Different serological methods testing association between antigen exposure and humoral response have been used in the past. Specific immunoglobulins G (IgG) testing is one of those more frequently used and commercially available.

Objectives: The aim of this pilot study was to estimate sensitisation of Czech HP patients to different inhalation antigens.

Patients: 254 HP patients diagnosed in years 2007-2015 were included. Diagnostic criteria concerned appropriate history and high resolution computed tomography finding eventually supported by bronchoalveolar lavage fluid lymphocytosis and histology (if available). Antigen exposure was detectable in history of 169 persons, in 85 no source of exposure could have been found.

Methods: All included patients underwent evaluation of specific IgG in serum, using ImmunoCAP method (Phadia, Sweden). Used specific IgG panel included mites, moulds, avian antigens, mammal proteins and professional antigens. Statistical differences between HP patients with known and unknown exposure were estimated using Mann-Whitney test. For antigens with statistically significant difference in serum concentrations in specific IgGs in patients with detectable and undetectable exposure, sensitisation values were regarded as mean (unexposed group) + SD (mg/L) and percentages of sensitised patients in the whole group were counted.

Results: In 63 patients we detected sensitisation to more than one antigen group (mould, mite, professional, avian)—39 patients exhibited sensitisation to moulds and mites, 28 mites and avian antigens, 25 moulds and avian antigens, 20 professional antigens (isocyanates) and moulds, 17 professional antigens and mites and 12 patients avian and professional antigens.

Conclusions: Presented study shows that the Czech HP patients in our study group are most commonly sensitised to hexamethylene diisocyanate (27.6% of HP patients) and diphenylmethane diisocyanate (26.3% of HP patients). Mite sensitisation is on the other hand the less common (D. pteronyssinus 14.6% of HP patients, D. farinae 15.5% of HP patients). Sensitisation to more than one antigen seems to be frequent.

Abstract Number: 1399

Link to conference website:

Link Conference abstract: 

EAACI 2017

Conference abstracts, posters & presentations

Showing 10 posts of 17225 posts found.
  • Title

    Author

    Year

    Number

    Poster


Our sponsors