Impact of outdoor molds on daily shortacting beta2 agonists (SABA) sales in central France area for 5 years

Author:

Caillaud DM 1; Cheriaux M 1; Sylvie M 2; Segala C 2; Dupuy N 3; Thibaudon M 3

Author address:

1 University Hospital, Auvergne University, Clermont-Ferrand, France; 2 Sepia-Sante, Baud, France; 3 Reseau National de Surveillance Aerobiologique, Brussieu, France

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2017

Abstract:

Introduction: No time-series study has investigated the relationship between daily SABA sales and outdoor mold spore levels. The aim of this study was to assess the short-term relationship between outdoor mold spore exposure and SABA sales over 5 years (2010- 2015) in an urban area (Clermont-Ferrand, 260 000 inhabitants) in central France.

Objectives: The relationship between daily changes in fungal spores (25 species) and daily changes in SABA sales obtained from the social security database was analyzed using generalized additive models, taking into account confounding factors such as air pollution, weather, pollens and days of the week.

Results: The relative risk: RR [95% CI Confidence Interval] of SABA sales in the whole population associated with an interquartile increase in mould concentration increased for Alternaria (Alt): 1.016 [1.001-1.031], Aspergillus/Penicillium (Asp-Pen): 1.013 [0.999-1.028], and Cladosporium (Cla): 1.039 [0.991-1.089]. When addressing the influence of gender and age, the relationship was significant only in boys 6 to 15 years for Alt: 1.066 [1.012-1.124] and Asp-Pen: 1.053 [1.021-1.085] and in males over 65 years old for Cla: 1.052 [1.001-1.106].

Conclusions: The association found between temporal changes in exposure to outdoor mould and daily SABA sales indicate that mould contributes to asthma and COPD morbidity in young boys and old males in the general population.

Abstract Number: 1623

Conference Year: 2017

Link Conference abstract: 

EAACI 2017

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