Herpes simplex virus reactivation in children and adolescents with acute leukaemia after allogeneic haematopoietic stem cell transplantation: in64258; uence of conditioning regimen intensity

Ref ID: 18625

Author:

S. Shiryaev, A. Chukhlovin, M. Popova, I. Neustroeva,
L. Zubarovskaya, B. Afanasyev

Author address:

R.M.Gorbacheva Memorial Institute of Children Hematology
and Transplantology (St. Petersburg, RU)

Full conference title:

Annual Meeting of the EBMT, 37th

Abstract:

Introduction: HSV is a signifi cant infectious pathogen in alloHSCT recipients. Organ and tissue damage, duration and intensity of immunosupression are among main triggering factors of
HSV reactivation. We supposed that allo-HSCT with reducedintensity conditioning (RIC) would decrease HSV reactivation
due to reduced organ and tissue damage.
Objectives: studying incidence of HSV reactivation in allo-HSCT
with myeloablative conditioning (MAC) vs RIC, and studies of
correlations between HSV reactivation and incidence/severity
complications in allo-HSCT.
Patient and methods. Fifty-four children and adolescents up to
21 years old with ALL and AML underwent matched related and
unrelated HSCT (either bone marrow or peripheral stem cells)
with MAC (n=31) and RIC (n=23) were included in the study.
HSV reactivation (HSV+) was detected by means of qualitative
PCR in blood, performed weekly both before and after engraftment until d+30. Toxic complications (hepatitis, neurological disorders etc) were determined according to appropriate criteria.
Results: We compared the incidence some toxic complications
(mucositis, severe mucositis, hepatitis, neurological disorders), occurrence of acute graft-versus-host-disease (aGVHD),
including aGVHD III-IV, intestinal aGVHD, hepatic aGVHD,
incidence of infectious complications, including aspergillosis
and sepsis in the following groups: “œallo-HSCT HSV+” vs “œalloHSCT HSV-“, “œMAC HSCT HSV+ vs MAC HSCT HSV-“, “œRIC
HSCT HSV+ vs RIC HSCT HSV-“, “œMAC HSCT HSV+ vs RIC
HSV+”, “œMAC HSCT HSV- vs RIC HSCT HSV-“. Observed difference in evaluated groups haven’t any statistical signifi cance,
only a strong tend to more frequent rate of infectious complications in “œallo-HSCT HSV+” group vs “œallo-HSCT HSV-“œ group
were observed, 88% and 39% respectively (p=0,057).
Conclusion: HSV reactivation may have some relations with
transplant-related morbidity, especially with other infections.

Abstract Number: P813

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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