Global fungal burden

Ref ID: 19353

Author:

D.W. Denning

Author address:

The University of Manchester, United Kingdom

Full conference title:

6th Trends in Medical Mycology 2013

Date: 11 October 2014

Abstract:

Few estimates of the global burden of fungal disease have been made.
In the Global Burden of Disease project 2010 update (Lancet 2012),
fungal skin diseases were the fourth most common health problem
affecting 985 miilion people after dental caries, tension-type head-
ache and migraine. Other global estimates are 1 million with crypto-
coccal meningitis complicating AIDS, 4.8 million with allergic
bronchopulmonary aspergillosis complicating asthma in adults (193
million adult of 334 million asthmatics total), 1.2 million patients
with chronic pulmonary aspergillosis following pulmonary tuberculo-
sis and about 75 million women with vaginal candidiasis 4 or more
times each year (5-8% of adult women under 50 years). Less robust
estimates include 400,000 cases of candidaemia, 100,000 cases of
Candida peritonitis, over 200,000 cases of invasive aspergillosis, over
400,000 cases of Pneumocystis pneumonia, and over a million cases
of fungal keratitis annually.
There is much variability of fungal infection frequency in different
countries (and probably different regions of large countries). The
number of people suffering and dying from fungal infections has been
estimated in 12 countries in which 3.1 billion people live, 45% of
the world’s population. Especially high incidence rates of Candida
bloodstream infection were found in Brazil (15/100,000) and Spain
(10.7/100,000), an extremely high rate of mucormycosis in India
(170,000 cases annually, 13/100,000) related to the burgeoning
epidemic of diabetes there, over 160,000 cases of invasive aspergillo-
sis in China (11.9/100,000), over 38,000 cases of cryptococcal men-
ingitis in AIDS in Uganda (110/100,000) and 75,000 and 18,000
cases of Pneumocystis pneumonia in Nigeria (48/100,000) and Brazil
(39.6/100,000) respectively. Estimates of tinea capitis were very
high in Africa, notably 15,580,000 cases in Nigeria (~50% of 155
million population are children) (1000/100,000) and 1,700,000
children affected in Kenya (4,300/100,000).
Modelling of fungal infection numbers requires confirmation with
local epidemiological studies. One such example is a 400 patient
study ongoing in Gulu, northern Uganda assessing the frequency of
chronic pulmonary aspergillosis after TB in HIV positive and negative
people, the former never previously studied.
References Brown GD, Denning DW, Gow NAR, Levitz S, Netea M,
White T. Human fungal infections: the hidden killers. Sci Transl Med
2012:4:165rv13.
Denning DW, Pleuvry A, Cole DC. Global burden of chronic pul-
monary aspergillosis as a sequel to tuberculosis. Bull WHO
2011;89:864-72.
Denning DW, Pleuvry A, Cole DC. Global burden of ABPA in
adults with asthma and its complication chronic pulmonary aspergil-
losis. Med Mycol 2013;51:361-70.
Key links: www.LIFE-Worldwide.org and www.fungalinfection-
trust.org/fungaldis.html

Abstract Number: ps1.1

Conference Year: 2013

Link to conference website: NULL

New link: NULL

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