Gentian violate can be used as topical oral anti-fungi and anti-stigma agent by people living with HIV/AIDS

Ref ID: 17768

Author:

E. Agwu*, J. Inyang, J. Ihongbe

Author address:

(Ishaka, UG; Ekpoma, NG)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Background: The challenges of poor reduction of oral fungal load are
complicated by rampant report of refractile (Multidrug resistant) oropharyngeal
Candidiasis, permitting the need to search for possible
alternative to current treatment regimen.
Objective: To demonstrate a concentration of gentian-violate effective
against oral yeasts but not stigmatize the patients by painting the mouth
with blue/violate.
Methods: Department of Microbiology, Kampala International
University, supplied for this investigation, the 148 (100 Candida
albicans, 10 Candida glabrata, 10 Candida norvegiensis, 6 Candida
parapsilosis, 6 Zygosaccharamyces species, 5 Candida tropicalis, 5
Saccharomyces cerevesieae, 3 Candida sake and 3 Saccharomyces
kliuverii) clinical oral yeast samples previously recovered from the oral
lesions of HIV/AIDS patients attending clinics in South-Western
Uganda. Standard methods were used to test the serially diluted 0.5%
gentian violate solutions against the oral yeasts.
Results: It was observed that 1:32 was the least dilution of 0.5%
gentian-violate which was able to give the minimum sensitive 14 mm
zone diameter according to CLSI with Candida albicans. Again 14 mm
zone diameter was obtained from 1:10 dilution of C. glabrata and C.
sake; while 1:8 dilutions of C. tropicalis, C. norvegensis, and C. sake
respectively. Topical (1:32 dilution of 0.5% GV) antifungal alternative
is cheap, available and will not stain the mouth thus removing
associated stigma.
Conclusion: Therefore, 1:32 dilution of 0.5% gentian-violate can be
used as topical anti-Candida albicans and 1:8 dilution of GV as topicalanti-
non Candida albicans respectively. This assures the efficacy,
availability and sustainability of oral fungal lesions treatment in
resource poor setting.

Abstract Number: NULL

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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