Fungiscope – A Global Database for Emerging Fungal Infections

Ref ID: 18799

Author:

M. J. Vehreschild, MD (Doctor of Medicine) – Physician 1, K. Wahlers, MD – Physician1, A. Hamprecht, MD – Microbiologist 1, G. Fischer, PhD – Professor 2, S. de Hoog, PhD – Professor 3, J. Vehreschild, MD – Physician 1, M. Karthaus, MD – Physician 4,

Author address:

1Univ. Hosp. Cologne, Koeln, Germany, 2Hlth. Authorities, Stuttgart, Germany, 3CBS, Utrecht, Netherlands, 4Klin. Neuperlach, Munich, Germany.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: We are coordinating a global registry for cases of rare invasive fungal diseases (IFD). Methods: Fungiscope – A Global Emerging Fungal Infection Registry uses a web-based electronic case form accessible via www.fungiscope.net. For inclusion in the registry we require positive cultures or histopathological, antigen or molecular genetic evidence of IFD and the associated clinical symptoms and signs. The data entered onto the registry include demographics, underlying conditions, neutrophil count, concomitant immunosuppressive medications, clinical signs and symptoms of IFD, site of infection, diagnostic tests performed, pathogen identification, antifungal treatment, surgical procedures performed, response to treatment, overall survival and attributable mortality. Results:
Overall, 268 cases have been completed. Zygomycetes (n=100; 37%), Fusarium spp. (n=46; 17%), yeasts (n=40; 15%), and Dematiaceae (n=32; 12%) were the most frequently registered pathogens. Chemotherapy or allogeneic stem cell transplantation for a haematological malignancy was the most predominant risk factor (n=125; 47%), as well as diabetes mellitus (n=64; 24%), stay at an ICU (n=48; 18%) and chronic renal disease (n=36; 13%). Sites of infection included the lung in 115 patients (43%), followed by blood stream infections (n=56; 21%), the sino-nasal region (n=43, 16%) and deep soft tissues (n=41; 15%). For 146 (54%) patients, a favourable outcome, defined as a complete or partial response to treatment of IFD was documented. Overall mortality and mortality attributable to IFD was 43% (n=116) and 31% (n=82), respectively. Conclusions: The clinical relevance of emerging IFD is increasing steadily. Further investigators are cordially invited to contribute to Fungiscope.

Abstract Number: M-338

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster