Fungal Infection in the Immunodeficient Host

Ref ID: 18711

Author:

Emmanuel Roilides, MD – Professor

Author address:

Aristotle Univ. Sch. of Med., Thessaloniki, Greece.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Many fungi come into contact with the host either as colonizing flora or as temporary invaders. Exemplary organisms with different host interplay are Candida and Aspergillus. Candida successfully colonizes body areas, such as gastrointestinal tract and vagina. Aspergillus spp. and other filamentous fungi challenge the respiratory tract daily and interplay with epithelial cells and macrophages. Different morphotypes evoke various degrees of virulence. One particular morphotype common in both Candida and Aspergillus with significant resistance to antifungal host defense is biofilms. Depending on how normal or deficient host immunity is (T-cell or innate) Candida may invade superficially and cause mucocutaneous candidiasis or translocate to bloodstream and cause various systemic infections (fungemia, acute candidiasis, organ-specific candidiasis and chronic disseminated candidiasis). By comparison, Aspergillus may be cleared by normal response or in the lack of qualitatively or quantitatively sufficient innate immunity (neutropenia, corticosteroids, CGD) may invade locally or even through blood vessels systemically.

Abstract Number: 1875

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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