Fungal colonization in interstitial lung diseases

Ref ID: 18422

Author:

Ilya Sivokozov , Olga Lovacheva, Eugene Shmelev, Elena Larionova.

Author address:

Endoscopy Dept, CTRI RAMS, Moscow, Russian Federation; Granulomatosis
Diseases Dept, CTRI RAMS, Moscow, Russian Federation; Microbiology Dept,
CTRI RAMS, Moscow, Russian Federation

Full conference title:

European Respiratory Congress

Abstract:

Background: Many of interstitial lung diasease are tend to impair the immunity,
thus patients in this group have a higher risk of fungal diseases. But still little is
known regarding the role of fungal colonization in interstitial lung diseases, when
fungi are not definite a causative agent.
Aim: To investigate the incidence and effects of fungal colonization of lower
respiratory tract using PCR of bronchaoalveolar lavage (BAL) specimens among
patients with sarcoidosis and extrincsic allergic alveolitis (EAA).
Materials: 132 patients with sarcoidosis, and 80 patients with EAA undergo
BAL with further PCR test for A. fumigatus and C. albicans using commercial
assays. Cytology of BAL, different disease parameters including functional tests,
radiology were analyzed.
Results: In sarcoidosis patients, Aspergillus was found in 22 cases (16.7%), 14
were males, and Candida detected in 11 cases (8.3%) – 3 were males. Among EAA
patients, Aspergillus detected in 13 cases (16.2%), 5 were males, and Candida in 9
(11.3%) cases, 4 were males. In sarcoidosis, Candida colonization was associated
with lower FVC (72%), DLCO (64%), and higher neutrophils level in BAL (32%),
as also disease duration (112.8 weeks) vs patients without it (92%, 88%, 9%
and 38.2 weeks, respectively). In EAA Candida detection was also associated
with lower DLCO (58%), 6-minute walk test distance (340 m), higher neutrophils
level in BAL (34%), disease duration (107.3 weeks) vs patients without it (72%,
421 m, 12% and 48.7 weeks, respectively). Aspergillus detection altered disease
parameters in similar way.
Conclusion: Colonization of respiratory tract with fungi in interstitial lung diseases
plays a prominent role in deterioration of disease.

Abstract Number: P3749

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

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