Functional and molecular analysis of newly identified sulfate transporter in pathogenic Fusarium species with respect to their  virulence and ability to infect potato.

Ref ID: 18491


Sebastian Pilsyk,
Hanna Gawinska-Urbanowicz,
Marzena Sienko,
Renata Natorff,
Urszula Perlinska-Lenart,Joanna Kruszewska

Author address:

Institute of Biochemistry and Biophysics, Polish Academy of Sciences  
The Plant Breeding and Acclimatization
Institute (IHAR)  

Full conference title:

11 th European Conference on Fungal Genetics


AstA protein (alternative sulfate transporter) represents a little known type of sulfate trasporter, belonging to an
extensive and poorly characterized family of allantoate permeases Dal5. In Aspergillus nidulans the astA gene is
under control of Sulfur Metabolite Repression (SMR). The closest homologs of astA are frequent in evolutionarily
distant fungi belonging to the Pezizomycotina subphylum (orders Sordariales and Eurotiales) which exhibit similar
plant pathogenicity. They are mostly crop pathogens and are represented by the following sequenced species:
Fusarium graminearum, F. verticillioides, F. oxysporum, Nectria haematococca, Verticillium albo8208;atrum, V. dahliae
and Leptosphaeria maculans. The AstA homolog is also present in: cellulolytic Chaetomium globosum detrimental
to paper industry, opportunistic human pathogen Neosartorya fischeri,  harmless Podospora anserina inhabiting
cattle dung, as well as in entomobiocontrol fungi like Cordyceps militaris and Metarhizium anisopliae.
Fusarium sp. fungi, like F. solani, F. oxysporum and F. sambucinum, contribute to  serious devastation of potato
crops and increase the  cost of cultivation due to application of pesticides. The main problem in the fight with plant
pathogenic fungi lies in their metabolic and protein similarity with the host. The aim of this project is to investigate
the function of AstA upon infection and colonization of plant host by fungal pathogens, like Fusarium sambucinum.
The study will involve infection of potato tubers with astA deletion mutant of F. sambucinum.

Abstract Number: PR4.58

Conference Year: 2012

Link to conference website:

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