First Diagnonstic of Invasive aspergillosis in Algeria by galactomannan test

Ref ID: 19477

Author:

M Chekiri1, Z Bouchene2*

Author address:

1Pharmacy, University Saad Dahlab, Blida, Algeria
2Pharmacy, University Benyoucef Benkheda, Algiers, Algeria

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Purpose:
The invasive aspergillose affects particularly patients with malignant pathologies in hematology
yards. Our hospital is an anti-cancer center located in Blida which is 50 km far away from Algiers.
During 3 years, 208 patients with severe neutropenia were included in our study .
Methods:
208 patients were included in our study, the average age is 33.60 years, standard deviation is
14.68 years, age between 16 and 72 ends, with a median of 30 years and mode 17. We conducted
various samples: sputum, samples from the mouth, nose, ears and finally sera for research
galactomannan. We used galactomannan test in serum as recommanded by EORTC/MSG twice a
week.
Thus, we conducted 94 sputum samples and 1039 swabs of the mouth, nose and ears. We obtained
669 serum with an average of 3.91 and a standard deviation of 2.41, the maximum number of
samples per patient was 9 and the minimum is 1 (the patient died). On the other hand we
explored the surrounding flora of these patients by withdrawal of objects (1160 samples) and air
(237 prí©lèvements). In total we obtained 3699 samples from patients, their environment and air.
Results:
58 patients involved in the study showed a positive serology galactomannan. According to the
criteria of the EORTC / MSG 16 patients among the 58 have probably developed a probable invasive
aspergillosis and 21 had false-positive serology.
Of all the different swabs of the mouth, nose and ears, carried out on 208 patients collected the
genus Aspergillus, and is ranked second after the yeast-like fungi. Aspergillus niger is ranked first,
followed by Aspergillus flavus, Aspergillus fumigatus is then third. According to the results of our
study of the environement Aspergillus niger is in the first position followed by Aspergillus flavus,
Aspergillus terreus, Aspergillus fumigatus and Aspergillus clavatus.
Conclusion:
Monitoring the serology is essential Aspergillus galactomannan in neutropenic patient hematology. It
must go through a full diagnosis involving radiological data including CT scan results of Aspergillus
serology and hoping that in the near future guided transmural biopsy .
The Aspergillus galactomannan technology now available in our country, make it easier to
identify invasive pulmonary aspergillosis cases dreaded disease in neutropenic leukemia. This
delicate technique requires for its interpretation of close collaboration between the mycologist
and hematologist. All data concerning the clinic, laboratory tests, treatment, are important, the
information sheet would be the key element of this interpretation.
In our study we found that 7.59% of patients in the Hematology CAC BLIDA suffer from probable
invasive aspergillosis. For the first time in our hospital, cases of invasive aspergillosis are described
the galactomannan test is very helpful in a developing country, where the molecular tests are so
expensive and not disponible.

Abstract Number: 5

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster