Farnesol8208;induced cell death in the filamentous fungus Aspergillus nidulans

Ref ID: 18443

Author:

Gustavo Goldman

Author address:

Universidade de São Paulo

Full conference title:

11 th European Conference on Fungal Genetics

Abstract:

FOH (farnesol), a non8208;sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been
shown to inhibit proliferation and induce apoptosis. We have been using Aspergillus nidulans and FOH as a model
system and cell death stimulus, respectively, aiming to understand by which means filamentous fungi are driven
towards cell death. Previously, we demonstrated that the A. nidulans calC2 mutation in protein kinase C pkcA was
able to confer tolerance to FOH. We demonstrate that pkcA overexpression during FOH exposure causes increased
cell death. FOH is also able to activate several markers of endoplasmic reticulum (ER) stress and the unfolded
protein response (UPR). Our results suggest an intense cross8208;talk between PkcA and the UPR during FOH8208;induced
cell death. Furthermore, the overexpression of pkcA increases both mRNA accumulation and metacaspases
activity, and there is a genetic interaction between PkcA and the caspase8208;like protein CasA. Mutant analyses imply
that MAP kinases are involved in the signal transduction in response to the effects caused by FOH.

Abstract Number: PS6.8

Conference Year: 2012

Link to conference website: http://www.ecfg.info/images/Abstract_Book_Electronic.pdf

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