Epidemiology of invasive fungal diseases in haematopoietic stem cell transplant recipients: preliminary analysis of a multicentre, prospective, observational study from Italy

Ref ID: 18577

Author:

C. Girmenia, S. Perrone, R. Ricci, A. Algarotti, A. Busca, A. Bosi,
P. Chiusolo, G. Irrera, E. Castagnola, L. Cudillo, B. Montante,

Author address:

A. Locasciulli on behalf of the Gruppo Italiano Trapianto
di Midollo Osseo (GITMO)

Full conference title:

Annual Meeting of the EBMT, 36th

Abstract:

Objectives: The purpose of our study was to describe the current epidemiology, incidence, risk factors and current diagnostic strategies for invasive fungal diseases (IFDs) in allogeneic
hematopoietic stem cell transplant (HSCT).
Methods: This prospective, observational, multicenter study
involved 30 HSCT Centers from Italy, started in January 2008
and is ongoing. Each Center reported data on consecutive
patients who underwent HSCT and data were collected until
1 year from transplant. The data collection is ongoing and preliminary data are now reported.
Results: To date, the baseline characteristics are available for
691 patients. Of them, 71 patients (10.3%) had experienced a
proven/probable IFD before HSCT. They were 53 (74.6%) invasive aspergillosis (IA), 12 invasive candidosis (IC) and 6 IFDs by
other fungi. Out of 515 patients evaluable at 100 days from HSCT,
53 (10.3%) developed a proven/probable IFD (IA, 46 cases; IC
5 cases; other IFDs, 2 cases). Out of 348 patients evaluable for
the follow-up from 100 to 180 days from HSCT, 15 (4.3%) developed an IFD. Finally, 5 IFDs (2.6%) were documented among
190 patients evaluable for the follow-up from 180 to 365 days.
Overall, according to these preliminary data, the incidence of
IFDs at 1 year from HSCT seems higher than 15%. According
to the data until now available at least 15% of patients with an
IA diagnosed before HSCT experienced an infection recurrence
within 100 days after transplant. Out of 58 cases of proven/probable IA documented after HSCT serum detection of Aspergillus
galactomannan antigen contributed to the diagnosis in 45 cases
(77.6%). At a preliminary analysis, the 3 months mortality rate for
HSCT recipients with an IFD was lower than 30%.
Conclusion: This is a prospective study on the “œreal life” epidemiology of IFDs in allogeneic HSCT population. The available
data show that IA remains the most commonly identifi ed IFD
and rates of survival appear to have improved, compared with
historical literature data.

Abstract Number: P725

Conference Year: 2010

Link to conference website: NULL

New link: NULL

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