Epidemiology of Candida bloodstream infections and antifungal susceptibility profiles: 10-year experience with 381 candidemia episodes in a tertiary care university centre

Ref ID: 17783

Author:

Sehnaz ALP, Sevtap ARIKAN-AKDAGLI, Dolunay GULMEZ, Sibel ASCIOGLU, Omrum UZUN, Murat AKOVA

Author address:

Hacettepe University Faculty of Medicine, Ankara, Turkey

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Candida spp. are the most common fungal pathogens responsible for invasive diseases
in humans. Among them, Candida albicans is in general responsible for more than half of
all Candida infections. However, recent studies showed a remarkable shift from C.albicans
to non-albicans Candida species (NAC) at least in a number of centres. Candida krusei is
known to be intrinsically resistant to fluconazole. Moreover, a decreased susceptibility to
fluconazole among other NAC, especially for Candida glabrata has been reported. The
changing epidemiology of candidemia and antifungal susceptibility data have an impact
on the preferred empirical antifungal regimen. This study was undertaken to (i) state
the ranking of Candida isolates among all positive blood cultures in our centre; ii) define
the species distribution of Candida strains responsible for bloodstream infections and
explore whether there is any potential increase in non-albicans Candida as compared to
C. albicans; and to (iii) determine the influence of currently approved CLSI breakpoints
on interpretation of antifungal susceptibility test (AST) results.

Abstract Number: P777

Conference Poster: y

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

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