Epidemiology and outcome of mucormycosis in hematopoietic stem cell transplant recipients

Ref ID: 19418

Author:

M. O. Popova,1 A. G. Volkova,1 V. Vavilov,1 S. N. Bondarenko,1
M. Y. Averjanova,1 N. V. Stancheva,1 O. V. Paina,1 E. V.
Morozova,1 S. N. Shiryaev,1 A. Gevorgyn,1 I. S. Zyuzgin,2 Y. V.
Borzova,3 S. N. Khostelidi,3 T. S. Bogomolova,3 L. S.
Zubarovs

Author address:

1I.Pavlov State Madical University, St.Petersburg, Russian
Federation; 2Leningrad Region Clinical Hospital, St.Petersburg,
Russian Federation and 3Department of Clinical Mycology, I.
Mechnikov Nord-Western State Medical University, St.Petersburg,

Full conference title:

6th Trends in Medical Mycology 2013

Date: 11 October 2014

Abstract:

Background In recent years mucormycosis (M) has become an
important cause of morbidity and mortality in allogeneic hematopoi-
etic stem cell transplant (allo-HSCT) recipients. This study focuses on
etiology, clinical forms and outcome of M and factors which influ-
ences on overall survival (OS) in allo-HSCT recipients.
Methods 14 pts with M after allo-HSCT were included in 2009-
2013 yy. Baseline patient characteristics and treatment are outlined
in Table 1. EORTC/MSG 2008 diagnostic criteria of proven and prob-
able invasive fungal disease (IFD) were used.
Results Incidence of M was 2,4% (14/582, allo-HSCT 2009-2012).
There were 6 proven (43%) and 8 probable (57%) cases of M in 14 pts
with predominantly acute leukemia (71%). Median date of M onset
after allo-HSCT was D + 105 (14-449). One case of M was diagnosed
post-mortally. Main clinical forms of M were pulmonary 79%, rhinoce-
rebral 7%, subcutaneous/osteomyelitis 7%, and bowel 7%. In 79% pts
bronchoscopy was performed, in 100% cases it was informative for the
diagnosis. In 57% of cases diagnosis was confirmed by culture. Etio-
logic agents of M were Rhizopus spp. (75%), Rhizomucor spp. (12.5%),
Mucor spp. (12.5%), and L. corymbifera (12.5%). In 50% cases M was
diagnosed after or with invasive aspergillosis (IA). 12-week OS after
diagnosis of M was 31%, 6-months OS in – 31%, and 1-year OS – 23%.

Abstract Number: p182

Conference Year: 2013

Link to conference website: NULL

New link: NULL

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