Environmental variables associated with the risk of invasive aspergillosis in haematological patients

Ref ID: 19239

Author:

C. Garcia-Vidal*, C. Royo-Cebrecos, M. Peghin, A. Moreno, I. Ruiz-Camps, C. Cervera, M. Labori, C. Gudiol Gonzalez, E. Rosello, J. Puig de la Bellacasa, J. Ayats, P. Barba, J. Carratalí 

Author address:

Barcelona, ES

Full conference title:

23rd European Congress of Clinical Microbiology and
Infectious Diseases

Date: 27 April 2014

Abstract:

Objective: Information regarding the environmental variables that may affect the incidence of invasive aspergillosis (IA) in hematological patients is scarce. We sought to determine the relationship between environmental factors (climatic conditions and circulating respiratory viruses) and IA in this population.
Methods: Retrospective observational cohort study of all hematological consecutive patients hospitalized with IA in three referral centers in Barcelona (2008-2011). We included cases of proven or probable AI according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) definitions. Data of climatic conditions (rainfall, humidity, wind and wind speed) were obtained from the Meterological Service of Catalonia. Data of circulating respiratory viruses were obtained from the Acute Respiratory Infection Surveillance Project in Catalonia (PIRIDAC).
Results: We identified 63 hematological patients with IA. Of these, 31 had acute myeloid leukemia and 12 had received stem cell transplantation. The IA diagnosis was based on one or more of the following: culture (29 cases), galactommanan (55), and histology (8). A total of 55 cases (87.3%) had criteria of probable IA and 8 (12.7%) of proven IA. Spearman Rho correlation demonstrated a significant inverse relationship between IA and wind and wind’s speed (-0.21; p=0.03 and -0.28; p=0.003). No relationship was found with IA admissions and other climatic conditions. The presence of circulating respiratory viruses was also associated with a higher risk of IA (0.19; p=0.05). Particularly, circulant influenza C was related with hospital admission for IA in patients with acute leukemia and SCT recipients (0.20; p=0.04).
Conclusions: According to our data, some environmental variables could modify the risk for developing IA in hematological patients. Physicians should be aware that circulating respiratory viruses are associated with an increased risk for developing IA to optimize the prevention and diagnosis strategies of IA during viral epidemic periods.

Abstract Number: O496

Conference Year: 2013

Link to conference website: http://registration.akm.ch/einsicht.php?XNABSTRACT_ID=163644&XNSPRACHE_ID=2&XNKONGRESS_ID=180&XNMASK

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