Environmental Variables Associated with an Increased Risk of Invasive Aspergillosis

Ref ID: 18733

Author:

M. Labori, MD – Physician 1, C. Garcia-Vidal, PhD – Physician1, M. Peghin, MD – Physician 2, A. Moreno, PhD – Physician 3, I. Ruiz, PhD – Physician 2, C. Cervera, PhD – Physician 3, C. Gudiol, MD – Physician 1, E. Rossello, MD – Physician 2, J. Bella

Author address:

1H. Bellvitge, L’Hospitalet (Barcelona), Spain, 2H. VallHebron, L’Hospitalet (Barcelona), Spain, 3H. Clinic, L’Hospitalet (Barcelona), Spain.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Information regarding the environmental variables that may affect the incidence of invasive aspergillosis (IA) is scarce. We sought to determine the relationship between climatic conditions (rainfall, humidity, temperature and wind) and IA. We also examined whether circulating respiratory viruses predispose to IA. Methods: Retrospective observational cohort study of all consecutive cases of IA hospitalized in three referral centers in Barcelona (2008-2011). Data of climatic conditions were obtained from the Meterological Service of Catalonia. Data of circulating respiratory viruses were obtained from the Acute Respiratory Infection Surveillance Project in Catalonia (PIRIDAC). Results: We identified 179 patients with IA. Main comorbid conditions were: haemathological malignances (54), stem cell transplantation (19), organ solid transplantation (32), severe immunosupressed patients (22), COPD (22), cancer (12), and others. The diagnostic was based on one or more of the following: culture (139 cases), galactommanan (102), and hystology (38). A total of 138 cases (77%) had criteria of probable IA and 41 (23%) of proven IA. IA was more frequent during spring and fall (58% of cases). None of the climatic conditions was associated with an increased risk of IA. Conversely, the presence of circulating respiratory viruses was associated with a higher risk of this infection. Spearman Rho correlation demonstrated a significative relationship between IA and Respiratory Syncytial Virus (0.30; p=0.002); Influenza A(H1N1) (0.25; 0=0.01), Influenza C (0.24; p=0.01), and Adenovirus (0.26; p=0.009). Conclusions: According to our data, circulating respiratory viruses appear to be associated with an increased risk for developing IA. Physicians should be aware of this association to optimize the prevention and diagnosis strategies of IA during viral epidemic periods.

Abstract Number: M-1228

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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