Elevated CEA levels in sera in patients with allergic bronchopulmonary aspergillosis (ABPA)

Ref ID: 18401

Author:

Hirotaka Matsuzaki, Wakae Tanaka, Yasuhiro Kojima, Masaki Kawakami,
Masaru Suzuki, Yoshio Sakamoto , Tadashi Horiuchi

Author address:

Respiratory Medicine,
Kanto Central Hospital, Tokyo, Japan; 2Internal Medicine, Okutama Hospital,
Tokyo, Japan

Full conference title:

European Respiratory Congress

Abstract:

Background: ABPA is an allergic disease associated with peripheral blood eosinophilia and elevated total IgE in serum. It sometimes accompanies with
bronchiectasis filled with mucus plug detected by chest X-ray- or CT films or
fiberotic bronchoscopy.Mucus plug is not infrequently misdiagnosed as lung tumor.
Carcinoembryonic antigen (CEA) is one of tumor markers and measured as a diagnostic
as well as surrogate marker of bronchogenic carcinoma. It has been reported
that some patients with ABPA demonstrated elevated CEA levels in their sera.
Aim: To evaluate clinical significance of serum CEA level in patients with ABPA.
Methods: Ten patients (6 women), aged from 39 to 78 (median; 67) with ABPA
were evaluated. All patients were never smokers or ex-smokers. Serum CEA level,
eosinophil number, total IgE, Aspergillus fumigatus (Af )-specific IgE- and precipitating
antibodies were measured. Chest roentgenogram and or CT were examined
when blood test was performed. For comparison, serum CEA levels were also
evaluated in patients with bronchiectasis (n = 20).
Results: Among 10 patients with ABPA, five demonstrated elevated serum CEA
levels (6.2 – 140.0 ng/ml; normal range 8804; 5 ng/ml). Massive mucus plugs were
demonstrated in four out of five patients on chest CT or X-ray films. Two out of five
patients were treated with systemic glycocorticosteroids resulting in the decrease
in CEA levels. Another patient showed the decrease in CEA spontaneously in
parallel with the decrease in eosinophil number.
Conclusion: Massive mucus plug may induce

Abstract Number: P473

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

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