Efficacy of Anidulafungin in Patients with Invasive Candidiasis (IC): Focus on non-albicans Candida spp

Ref ID: 18786

Author:

U. Conte, PharmD – Clinician1, P. Hogan, MS – Medical Director 1, H. Schlamm, MD – Medical Development Lead 1, P. Biswas, PhD – Statistician 1, B. Kullberg, MD, PhD – Professor of Medicine 2, M. Ruhnke, MD – Professor of Medicine 3;

Author address:

1Pfizer Inc., New York, NY, 2Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands, 3Charité Univ.smedizin, Berlin, Germany.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Over the past decade there has been a steady increase in the prevalence of non-albicans Candida spp. in patients with IC. The recent completion of 4 similar prospective, open-label, non-comparative studies conducted in the USA, Canada, Latin America, Europe and Asia allowed us to create a large database of patients treated with anidulafungin and enabled us to assess efficacy in patients with non-albicans Candida spp. infection, including C parapsilosis. Methods: Data from patients with microbiologically-confirmed IC enrolled in these 4 regional studies were pooled into a database. Each patient was initially treated with IV anidulafungin with an option to step down to an oral azole. Total treatment duration was ≥ 14 days. Global response (based on investigator-assessed clinical and microbiological response) was assessed at the end of IV anidulafungin therapy and end of all antifungal therapy (primary endpoint). Results: A total of 256 and 253 patients with documented Candida infection due to Candida albicans and non-albicans Candida spp. (C glabrata, C parapsilosis, C tropicalis, C krusei), respectively, were analyzed. Rate of successful global response and all-cause mortality is shown below:
Conclusion: In this large database of patients treated with anidulafungin for IC, there were adequate numbers to assess response rates in non-albicans Candida spp.. Response rates in patients with infection due to C glabrata and C parapsilosis were also remarkably high and similar to C albicans.

Abstract Number: M-1683

Conference Poster: y

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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