Effect of recurrent growth of aspergillus on lung function in paediatric population with cystic fibrosis (CF)

Ref ID: 18425


A. Adams, R. Thursfield, A. Bush.

Author address:

Paediatric Respiratory, Royal Brompton
Hospital, London, England, United Kingdom

Full conference title:

European Respiratory Congress


Background: Allergic bronchopulmonary aspergillosis (ABPA) is well described
in CF. Many CF patients grow Aspergillus fumigatus (AF) on sputum and cough
swabs but do not have ABPA. There is evidence that this is clinically important
[Chest 2006;130:222, Ped Pulm 2007;42:785]
Hypothesis: Isolation of AF from sputum or cough swab is associated with a
worse clinical state in CF children.
Methods: A retrospective cohort study of all children with CF who had sputum
samples or cough swabs positive for AF on >1 occasion at least one month apart
between 2008 and 2010. Lung function results and nutritional status were recorded.
Results: 35 children (15 male) were identified who fit the criteria, mean age 11.2
years (SD2.1) mean BMI 17.5. Data were collected on 21 controls (7 male) with
CF who had not grown AF during the study period and had never had a diagnosis
of ABPA, mean age 11.12 years (SD2.21) mean BMI 17.2. Children with AF had
a lower mean FEV1(p<0.0001) over the follow-up period (69.8, SD13.8 vs 89.4, SD11.5), despite a greater number of days of intravenous antibiotics (45 days vs. 2.6 days in the 2 year period (p<0.0001)) Conclusions: Recurrent growths of AF are associated with a worse clinical state, manifest by lower lung function, despite the use of significantly more intravenous antibiotics.

Abstract Number: P4564

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

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