Direct detection of resistance: candins vs. azoles

Ref ID: 19463

Author:

D. Perlin

Author address:

Rutgers University, Newark, USA

Full conference title:

6th Trends in Medical Mycology 2013

Date: 11 October 2014

Abstract:

Antifungal drug resistance threatens therapeutic effectiveness and
needs to be diagnosed in a timely manner. Currently, recognition of
antifungal resistance still relies on culture-based susceptibility testing.
Yet, antifungal susceptibility testing is not routinely performed and
often comes too late to influence a timely decision on patient man-
agement. As molecular technology continues to evolve and accrued
insights on antifungal drug resistance mechanisms deepens, some
novel molecular techniques are now available to provide a faster,
more sensitive and accurate assessment of both primary and
acquired resistance than classical methodologies. Validated targets
for echinocandin resistance in Candida spp. and triazole resistance in
Aspergillus fumigatus and Candida spp. are particularly well suited for
molecular detection. Despite the availability of robust technology,
routine implementation of a molecular diagnostic platform for drug
resistance within a clinical setting requires validation in well-
designed clinical trials, as well as improved and automated methods
for highly efficient primary sample preparation.

Abstract Number: w12.3

Conference Year: 2013

Link to conference website: NULL

New link: NULL

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