Differences in clinical characteristics between aspergillus fumigatus sensitized asthmatics and allergic bronchopulmonary aspergillosis


Haisheng Hu

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European Academy of Allergy and Clinical Immunology Congress 2019


Aspergillus fumigatus sensitized asthma patients (AFSA) are prone to develop into allergic bronchopulmonary aspergillosis (ABPA). This study aims to explore the characteristic of these patients and accurate diagnosis between diseases.

The sIgE of Aspergillus fumigatus was detected by ImmunoCAP 1000 system in 17 patients with ABPA and 14 patients with AFSA. The sIgG of Aspergillus fumigatus was detected by Aspergillus fumigatus specific IgG ELISA kit (DRG). Clinical data such as pulmonary function and blood routine were collected.

There was no significant difference in blood routine and induced sputum between ABPA and AFSA patients, but the levels of sIgG [2294.00 U/mL (1527.00, 14170.00) vs. 972.60 U/mL (650.90, 1792.00)], sIgE [8.77 kU/L (1.64, 16.85) vs. 1.04 kU/L (0.70, 2.05)] in ABPA patients were significantly higher than those in AFSA patients (P < 0.05). Aspergillus fumigatus sIgG was strongly correlated with Aspergillus fumigatus sIgE (rs = 0.797, P < 0.001) in ABPA patients , but weak in AFSA patients. When combined with Aspergillus fumigatus sIgE (> 1.00 kU/L) and Aspergillus fumigatus sIgG (> 1000.00 U/mL) for the differential diagnosis of ABPA and AFSA, the sensitivity and specificity reached 82.3% and 78.6%

ABPA patients have higher levels of sIgE and sIgG of Aspergillus fumigatus than AFSA patients. Combination of sIgE and sIgG of Aspergillus fumigatus to diagnosis ABPA and AFSA patients is important.

Abstract Number: TP1509

Conference Year: 2019

Link Conference abstract: 

EAACI 2019

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