Development of Treatment Costs of Patients Undergoing Remission Induction Chemotherapy: A Historical Comparison Before and After Introduction of Posaconazole Prophylaxis

Ref ID: 18790

Author:

S. Heimann, Masters (MA or MS) – Scientist, O. Cornely, Professor of Medicine – Scientist, H. Wisplinghoff, MD – Scientist, M. Vehreschild, MD – Scientist, B. Franke, data manager – Scientist, J. Glossmann, MD – Scientist, J. Vehreschild, MD – Scient

Author address:

Univ. Hosp. of Cologne, Cologne, Germany.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Prior trials have demonstrated efficacy & effectiveness of posaconazole (POSA) in the prophylaxis (proph) of invasive fungal diseases in high-risk patients (pts). We performed an analysis comparing the direct costs (cts) of POSA proph vs. topical polyene (TOPO) (thrush) proph in pts. with AML and MDS. Method: Data of AML/MDS pts. receiving remission-induction chemotherapy were analysed to compare hospital cts of pts before (2003-05) & after (2006-08) introduction of POSA proph. Duration on general ward & ICU, mechanical ventilation, diagnostic procedures & all anti-infectives were analysed. Results: Patient groups were well matched in baseline characteristics. The average cts per patient (pp) in the POSA group (n=76) & the TOPO group (n=81) were 21,040 € (95% CI: 18,204-23,876 €) & 23,169 € (95% CI: 19,402-26,937 €) pp, respectively. Antifungal treatment cts were nominally higher in the POSA group (4,580 € [95% CI: 3,678-5,482 €] vs. 4,019 € [95% CI: 2,825-5,214 €]). The cts for antibacterials (1,316 € [95% CI: 1,039-1,593 €] vs. 1,533 € [95% CI: 1,238-1,827 €]) were numerically decreased in the POSA group. Average duration of ICU stays were 1.79 (95% CI: 0.68-2.90) days pp vs. 3.83 (95% CI: 1.53-6.13) days pp. Cts for diagnostic procedures were 611 € (95% CI: 478-744 €) & 653 € (95% CI: 552-754 €) pp, respectively. Conclusion: In our hospital, there was a trend towards cost-saving by POSA proph. These savings were primarily caused by a shorter length of stay & the less frequent ICU treatment.

Abstract Number: M-1706

Conference Poster: y

Conference Year: 2012

Link to conference website: NULL

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