Comparative mRNAs expression patterns between vegetative growth and asexual development in Aspergillus nidulans.

Ref ID: 18279

Author:

Aitor Garzial, Julio Rodrguez-Romero, Reinhard Fischer, Eduardo A. Espeso and Unai Ugaldel.

Author address:

Dept. of Applied Chemistry,
Faculty of Chemistry, University of The Basque Country. Manuel de Lardizabal, 3, 20018, San Sebastian, Spain. 2. Karlsruhe Institute
of Technology, Institute for Applied Biosciences, Department of Microbiology, D-76187

Full conference title:

Asperfest 9

Abstract:

Using the high resolution RNA-Seq, we have analyzed the different mRNA expression patterns between vegetative and asexually
developing mycelia of Aspergillus nidulans. The pathways and genes that are activated and repressed during vegetative hyphal growth
and conidiophore production have been identified. We also describe a substantial number of novel transcripts that are controlled by
Upstream Developmental Activators (UDAs, especially FlbB) at different stages of development. Genes involved in secondary
metabolism (like polyketide synthases, see poster Rodrguez-Urra et al.), increased oxidoreductase activity and/or transcription factors
(principally binuclear zinc clusters) are examples of groups regulated by FlbB. Our analysis indicates that during asexual development
the 4% of the transcriptome is modified comparing with vegetative growth, including more genes than previously were anticipated. Of
these, FlbB regulates the 60% directly or indirectly. These results may provide a blueprint for further study of the Aspergillus nidulans
development. Keywords: Aspergillus nidulans, asexual development, conidiophore, transcription factor, mRNA sequencing.

Abstract Number: 25)

Conference Year: 2012

Link to conference website: NULL

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