Comparative analysis of mitochondrial genomes from Aspergillus and Penicillium spp

Ref ID: 18328

Author:

Vinita Joardar, Suman Pakala, Jessica Hostetler, Suchitra
Pakala, Natalie Fedorova and William Nierman

Author address:

J. Craig Venter Institute, Rockville MD, USA.

Full conference title:

Asperfest 8

Abstract:

Fungal mitochondrial genes are widely used in population and phylogenetic studies and have been linked to virulence and senescence in some fungi. While
multiple nuclear genomes are available for Aspergillus spp., few annotated mitochondrial genomes have been published for these organisms. We report
here the complete sequence of 6 mitochondrial genomes of Aspergillusspp. as well as 3 Penicillium spp. obtained by Sanger sequencing. While core gene
content and synteny are well conserved within each genus, the genomessizes range considerably from 24,658 to 35,056 bp in Aspergillus spp. and from
27,017 to 36,351 bp in Penicillium spp. The core mitochondrial genome includes the 14 genes involved in oxidative phosphorylation, a complete set of
tRNAs, the small and large subunits of ribosomal RNA and the ribosomal protein S5, all encoded on the same strand. The differences in size correlate
with the number of introns and the number of accessory genes present in the genome. The smallest genomes do not contain introns in the protein-coding
genes whereas the larger genomes contain as many as 9 introns. Accessory genes include intron-encoded endonucleases, DNA and RNA polymerases
and hypothetical proteins. The comparative and phylogenetic analysis of these and related publicly available mitochondrial genomes are presented.
Funding: NIAID

Abstract Number: 6)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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