Combination of invasive aspergillosis and invasive candidiasis in hematological patients

Ref ID: 19563

Author:

E Shagdileeva1*, S Khostelidi1, E Raush1, T Bogomolova1, S Ignatyeva1, N Klimko1

Author address:

1I.I. Metchnikov North-Western State Medical University, Saint-Petersburg, Russia

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Objective:
Invasive aspergillosis (IA) and candidiasis (IA) are leading causes of morbidity and mortality in
haematological patients. Publications about combination of IC and IA in haematological patients
are limited.
Methods:
The prospective study was conducted during the period 2012-2013 y.y. Diagnosis of IA and IC was
made according to EORTC/MSG criteria (2008).
Results:
We observed 3 hematological patients with IA and IC. The mean age of our patients was 42 years
(range 36-58), male and female ratio 1:2. Underlying conditions were: acute myeloid leukemia – 2,
non-Hodgkin’s lymphoma – 1.
Test «Platelia Aspergillus EIA» (Bio-Rad) was positive in all of patients in blood and BAL.
A. flavus in BAL – 1 patient.
Diagnosis of IC was confirmed by culture of blood. The agents of IC were C.krusei, C. parapsilosis
and unidentified Candida.
The main sites of IA and IC were lungs (100%), sinuses (67%), skin and soft tissues – (33%). More
then one organs were affected in all of patients.
Antifungal therapy was performed all of patients: voriconazole – 100%, fluconazole – 67%,
amphotericin B deoxycholate – 67%%, caspofungin – 67%%, amphotericin B lipid complex
– 33%, micafungin – 33%. Combination therapy voriconazole + amphotericin B, voriconazole+
caspofungin, voriconazole+ micafungin was used for 67% patients.
Duration of antifungal therapy was 11 – 167 days (median – 120). Necrosectomy of nasal soft tissues
was performed in 1 patients. Overall survival at 12 weeks was 2/3 of patients.
Conclusion:
Combination therapy can be successful in the treatment of combination of invasive aspergillosis and
candidiasis in haematological patients.

Abstract Number: 90

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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