Co- infection of probable invasive pulmonary aspergillosis and cutaneous Fusarium infection in a patient with pyoderma gangrenosum : a case report

Ref ID: 19582

Author:

A Abdollahi1*, N Amirrajab1,2,3, M Aliyali4, S Mayahi5, N Najafi6, R Abdi7, O Nourbakhsh8,
T Shokohi5,9

Author address:

1Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of
Medical Sci, Ahvaz, Iran
3Tropical Medicine Research Center, Ahv

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Purpose:
Invasive fungal infections (IFIs) have an increased frequency in immunocompromised patients and
are major causes of morbidity and even mortality.
Case Presentation:
We report an unusual case of probable invasive pulmonary aspergillosis (IPA) caused by Aspergillus
flavus and fusarial skin infection caused by Fusarium proliferatum in patient with chronic pyoderma
gangrenosum (PG) which was previously controlled with oral prednisolone, cyclosporine. The
diagnosis of probable IPA and cutaneous fusariosis caused were made on the basis of direct
microscopic examination, culture of endobronchial washing and bronchoalveolar lavage (BAL) and
tissue samples which was confirmed by PCR sequencing. Lung biopsies was not performed because
of his critical condition. The patient underwent systemic antifungal therapy with voriconazole. The
treatment failed and the patient expired 12 days following hospitalization.
Conclusion:
This report highlights the rarity of coexistence of IPA and a chronic fusarial skin infection and
thereby reinforcing the physicians, attention towards the possibility of invasive fungal infection in
the immunosuppressed patients.

Abstract Number: 107

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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