Clinical characteristics of ocular candidiasis: when should fundoscopy be performed to rule out ocular candidiasis?

Ref ID: 17743

Author:

M. Nagao*, T. Saito, G. Hotta, S. Doi, M. Yamamoto, Y. Matsumura,
A. Matsushima, Y. Ito, S. Takakura, S. Ichiyama

Author address:

(Kyoto, JP)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objectives: Ocular candidiasis is a major complication of Candida
bloodstream infection (BSI), but littile information is known about
the clinical characteristics. This study was conducted to investigate the
incidence, risk factors and the outcome of ocular candidiasis and the
optimal timing of fundoscopy.
Methods: We analyzed 216 cases with positive blood cultures of
Candida species from January 2005 to June 2011 in two teaching
hospitals to determine the incidence and the clinical characteristics of
ocular candidiasis. Infectious diseases physicians in these hospitals
performed proactive intervention in all of the Candida BSI cases and
recommended fundoscopic examinations by ophthalmologists.
Results: One-hundred sixty three of 216 Candida BSI cases had
opthalmology consultations during the course of the antifungal therapy.
Fifty-three (32.5%) cases had findings consistent with the diagnosis of
ocular candidiasis, consisting of 44 cases with possible/probable
chorioretinitis and nine cases with vitreitis. The groups with and
without ocular involvement did not differ in age, sex, steroid use or
diabetes mellitus, but more cases had digestive organ abnormalities or
malignancies. Of these 53 cases, 42 (79.2%) were diagnosed within
7 days after a positive blood culture. The average time from a positive
fungal culture to the diagnosis was 5.5 days. Twelve ocular candidiasis

Abstract Number: NULL

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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