Chronic pulmonary aspergillosis: Characteristics of 30 nonimmunocompromised patients

Ref ID: 18411

Author:

Boubou Camara, Bernadette Lebeau, Christel Saint-Raymond ,
Gilbert Ferretti , Jaques Cadranel, Herve Pelloux, Christophe Pison.

Author address:

Clinique de Pneumologie, Hôpital Michallon, Grenoble, France; Laboratoire
de Parasitologie-Mycologie, Hôpital Michallon, Grenoble, France; Clinique
d’Imagerie Médicale, Hôpital Michallon, Grenoble, France; Clinique de
Pneumologie, Hôpital Tenon, P

Full conference title:

European Respiratory Congress

Abstract:

Introduction: Chronic pulmonary aspergillosis (CPA) is a severe respiratory infection
characterized by pulmonary cavities and increased levels of antibodies to
Aspergillus specie. We describe 30 nonimmunocompromised patients with CPA.
Materials and methods: Multidisciplinary working group devoted to epidemiological
surveillance of invasive aspergillosis was created in our hospital in January
2000. Among 1545 alerts, 30 cases of CPA in nonimmunocompromised patients
were identified. In a retrospective study, we investigated characteristics of patients
with CPA.
Results: 30 patients were identified. Their mean age was 69.2 years (interquartile
range (IQR) 43.8 – 83.9 years) and 19 (63%) of the patients were men. 19 (63%)
of patients had a smoking > 10 pack-years, 23 patients (77%) had COPD, 6
patients in GOLD stage IV and 8 patients in GOLD stage III. All had detectable
Aspergillus spp precipitins and inflammatory markers. Aspergillus spp was isolated
in respiratory specimens of 16 (53%) patients. The radiological improvement was
essentially: excavations (n=19, 64%); consolidation (n=14, 47%); bronchiectasis
(n=12, 40%), nodules (n=9, 30%) and sequelae of tuberculosis (n=5, 17). The
average duration of follow up was 31.5 months (IQR 0.2 – 131 months). The
average duration of treatment was 7, 6 months (IQR 0.2 – 23 months). The outcome
was favorable in 18 (60%) patients and negative in 14 (40%) patients significantly
correlated with the degree of bronchial obstruction.
Conclusion: CPA typically occurs in patients with preexisting structural lung disease,
and it causes significant respiratory and constitutional symptoms. Prospective
studies are required to better characterize the profile of patients.

Abstract Number: P2516

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

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