Chronic necrotizing pulmonary aspergillosis: characteristics and risk factors. retrospective study of 35 hospitalized patients NPCA (2002-2008).

Author: C. Rouyer

Full conference title:

Réunion Interdisciplinaire de Chimiothérapie Anti Infectieuse

Date: 16 May 2016


Aspergillus fumigatus is a leading fungal pathogens responsible for airborne and pulmonary tropism of various pathologies of the spectrum according to the patient’s field, its factors of immunosuppression, or its underlying lung diseases. The Pulmonary Aspergillosis Chronic Necrotizing (NPCA) or invasive aspergillosis semi remains difficult and late diagnosis.

Objectives: This retrospective study aims to determine the characteristics and risk factors of the subpopulation of patients with NPCA compared with “HIV positive” patients with positive serology without aspergillus aspergillus evolutionary pathology.

Methods: The patients studied were recruited unit of Pneumology Hospital from the register of Aspergillus positive serological tests between 2002 and 2008. The diagnosis of NPCA is made ​​according to the criteria of Denning.

Results: One hundred and five patients were included in the study. The average age was 59 years (+/- 16.4 years) and 70 patients (67%) were men. Thirty-five patients (33%) had NPCA and forty were “seropositive” without progressive aspergillosis disease at follow up. Patients CNRPA more frequently had a history of mycobacterial infection (p = 0.047). Clinically it is most frequently found a symptom hemoptysis (p = 0.025).Radiologically we noted a significantly higher frequency of excavations, infiltrates and pleural effusions. Finally the aspergillus serology arches was significantly higher in patients with NPCA (p = 0.001).

Keywords : chronic pulmonary aspergillosis necrotizing Aspergillus serology.

Conference Year: 2012

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