Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder contributing to lung disease in cystic fibrosis (CF). Although different criteria have been proposed diagnosis of ABPA in clinical practice remains challenging.
Objectives: This study analyzed the predictive value of total IgE (t-IgE) levels in a CF cohort alongside
Methods: 387 children and young adults were followed from 2000 to 2006 and retrospectively classified into four groups.
Patients showing t-IgE levels below the 95th percentile were categorized as “Aspergillus fumigatus (Af) naïve” and “AS sensitized” if specific Af-IgE were present. The term “Former ABPA” was used in patients with elevated t-IgE levels at study entrance, while the “ABPA at risk” group contained patients whose t-IgE values exceeded the 95th percentile during the study period. The t-IgE courses were divided into episodes of change (ΔIgE episodes) and effects of
Results: 125 (32%) patients were found to be Af naïve and 64 (17%) were Af sensitized. 81 ABPA
Conclusion: In ABPA diagnosis, analyzing the course of t-IgE levels predicts the effect of treatment on pulmonary outcome.
Full conference title:
- ERS 26th (2016)