A. fumigatus is a truly dimorphic fungus characterized by a vegetative morphotype, themycelium, and a quiescentmorphotype, the conidium, which is the infective propagule and only germinates when it encounters a suitable host environment. The cell wall plays a major role during infection. The interactions between the different pattern-recognition receptors and cell wall pathogenassociated molecular patterns orientate the host response toward either fungal death or growth, which would then lead to disease development. For years, the cell wall was considered as an inert exoskeleton of the fungal cell. The cell wall is now recognized as a living organelle, since the composition and cellular localization of the different constitutive cell wall polymers vary when the fungus senses the changes in the external environment. During my talk, I will review recent data focused on the composition and synthesis of the outer layer of the cell wall of the conidium and mycelium and their impact on the initiation of the immune response.
Full conference title:
- ISHAM 20th (2018)