Candidaemia in hospital, Como, Italy, from 1997 to July 2011 and sensitivity to antifungal drugs

Ref ID: 17736

Author:

E. Sala*, R. Mauri, S. Armitano, T. Tamborini, L. Villa, G. Tagliabue,
V. Caneva, D. Santoro, G. Giana

Author address:

(Como, IT)

Full conference title:

22nd European Congress of Clinical Microbiology and Infectious Diseases

Abstract:

Objectives: Candidemia 1997-July 2011 and evaluation of antifungal
drugs referring to EUCAST and CLSI breakpoints are reported.
Methods: Blood culture was performed by automated system, and
those samples positive for yeast were subcultured on Sabouraud agar
and Chromagar Candida (BD); Candida identification: Auxacolor
(Remel) and Yeast card VITEK2 (bioMerieux); antifungal
susceptibility: Sensititre Yeastone.
Results: Since 1997 to July 2011, 155 candidemia were detected: C.
albicans 82 (53%), C. glabrata 26 (17%), C. parapsilosis 29 (19%), C.
tropicalis 10 (6%), other species eight cases (5%). Eighty-two cases
occurred since 1997 to 2007, with 7.4 cases/year; since 2008 there was
an increase with 73 candidemia until July 2011 and 20.3 cases/year.
Candidemia cases April 2010-July 2011: 39 cases, 16 males (41%) and
23 females (59%). C. albicans is the species most frequently found with
20 isolates (51%); C. glabrata 10 isolates (26%); minor surveys of
candidemia from other Candida species (C. famata, C. krusei, C.
lusitaniae, C. parapsilosis and C. tropicalis). Sensititre provides MIC
for different antifungal drugs. C. albicans: 17 isolates susceptible to
fluconazole and voriconazole based on CLSI, 16 based on EUCAST;
referring to posaconazole, 17 susceptible with CLSI breakpoint, 13
based on EUCAST; there are no differences for anidulafungin and
amphotericin-B with all the isolates susceptible. All C. glabrata isolates
result susceptible to anidulafungine and amfotericin-B. Two out of three
isolates of C. parapsilosis and two isolates of C. tropicalis are resistant
to posaconazole with EUCAST and susceptible with CLSI. There were
no differences for Candida spp. with anidulafungin and amphotericine
B.
Conclusions: Over the past 14 years, there has been a significant
increase in Candida spp. bloodstream infections; non-albicans Candida
species reach almost half of the Candida isolates; C. albicans EUCAST
breakpoints show an increase of isolates resistant to fluconazole,
posaconazole and voriconazole; the use of antifungal susceptibility test
is now mandatory.

Abstract Number: NULL

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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