Burden of serious fungal infection in Iran

Ref ID: 19405

Author:

M. Hedayati,1 M. Tagizadeh,2 J. Yazdani Charati3 and
D. W. Denning4

Author address:

1Mazandaran University of Medical Sciences, Sari, Iran;
2Department of Medical Mycology and Parasitology, School of
Medicine, Mazandaran, Sari, Iran; 3Department of Statistics,
School of Health, Mazandaran University of Medical Sc, Sari, Iran
and

Full conference title:

6th Trends in Medical Mycology 2013

Date: 11 October 2014

Abstract:

Objectives Iran is a Middle East country with a diverse range of cli-
matic conditions in different areas. In last two decades, Iran has
made significant improvements in the health system including apply-
ing advanced procedures in management and diagnostic methods.
There are many transplants, cancer and intensive care unit centers.
Nowadays, fungal disease diagnosis is not confined to cutaneous
mycoses but includes life threatening mycoses because of their impor-
tance for survival. There are many reports on serious fungal diseases
in Iran which we reviewed comprehensively. Method To identify the literature on fungal diseases in Iran, we
searched Medline and several national databases of Iran. We searched
meeting abstracts, too. We excluded case reports. We used specific pop-
ulations at risk and fungal infection frequencies in the population to
estimate national incidence or prevalence. Population statistics were
derived from the Statistics National Organization of Iran.
Results Of Iran’s 72,874,050 populations, 50.9% are male and
49.1% are female. Estimates are: 2,188,323 Iranian women get
recurrent vaginal thrush; 175,569 children have tinea capitis. Esti-
mation for burden of oral candidiasis was 133.6 per 100,000 popu-
lations at risk. Total burden and estimation for burden of IA in
cancer patients were 251 and 0.33%, respectively. The estimation
for burden of ABPA in asthma patients was 1.36%. Based on the
24,735 cases of HIV infection reported, an estimated 1,472 cases of
Pneumocystosis is estimated. Based on our review, Aspergillus flavus
was the most common isolated species among Aspergillus spp. in IA
patients. Candida albicans was the prevalent species of Candida in can-
didiasis. Mucormycosis cases were only confirmed by histopathologi-
cal method and etiologic agents were not identified by culture.
Conclusion The reported incidence of invasive mycoses among im-
munocomporomised patients from Iran is considerably high in com-
parison with those of developed countries. Interestingly, A. flavus is
the most prevalent specie of Aspergillus in IA patients which is differ-
ent with the findings of the most other studies from different coun-
tries. Substantial uncertainty surrounds these estimates and
epidemiological studies are urgently required to validate or modify
these estimates.

Abstract Number: p139

Conference Year: 2013

Link to conference website: NULL

New link: NULL

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