Association of airborne Aspergillus with asthmatic adult patients : Evidence from South India


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Purpose: Exposure to airborne fungi has been related with asthma in adults and children leading to increased outpatient, emergency room visits, and hospitalizations. Hypersensitivity to these airborne fungi may be an important initial predisposing factor in the development of asthma.This study was conducted to determine an association between fungal types and spore concentrations with the risk of asthma in adults.

Methods: This cross-sectional study was conducted from March 2014 to August 2016 at two tertiary government Hospital Kerala. All adult (age≥16 years) patients presenting to the hospital with acute asthma were enrolled after informed consent. A home survey was conducted for each patient to assess their environmental characteristics. Indoor air samples were also obtained from the patient’s home to determine the type and spore concentration of fungi within the week of their enrollment in the study.

Results: Two hundred and thirty-one patients with an acute asthma were enrolled during the study period. The mean age of participants was 43 years (standard deviation, ±15 years). A trend of higher asthma enrollment associated with higher Aspergillus concentrations was found in two consecutive summers. A total of nineteen types of fungi were found in air samples. Aspergillus spp. was the most frequently isolated fungus with acute asthma exacerbation.

Conclusion: An association of higher concentration of indoor Aspergillus spp. with asthma in adults was observed in this study.


Full conference title: 

The 8th Advances Against Aspergillus, Lisbon Conference Center, Lisbon, Portugal
    • AAA 8th (2018)