Aspergillus terreus as an emerging cause for pulmonary fungus ball : a case report

Ref ID: 19556

Author:

A Rezaei-Matehkolaei1*, A Rafiei2, S Jafarpour1, MJ Najafzadeh3

Author address:

1Department of Medical Mycology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Deprartment of Medical Laboratory Sciences, Para-Medical Faculty, Jundishapour University of Medical
Sceinces, Ahwaz, Iran
3Department of Parasitology

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Introduction:
Based on epidemiological studies, Aspergillus terreus has been demonstrated as an emerging fungal
agent of pulmonary fungus ball. Here we describe a case of pulmonary fungus ball due to Aspergillus
terreus in a 30-year-old Iranian female.
Case:
The patient had a history of bilateral pulmonary echinococcal (hydatid) cyst surgery. However,
clinical signs/symptoms were weight loss, dyspnea and chronic persistent cough but not fever and
haemoptysis. No evidences were seen for fasciolosis, HIV and tuberculosis infections.
Dichotomously branched hyphae were observed in direct microscopy of bronchoalveolar lavage
(BAL). Several inoculation of BAL samples on sabouraud’s medium wae indicative for Aspergillus
Section Terrei. Sequencing of RNA polymerase II (RBP2) and Beta tubulin (BT2) genes confirmed
the identity of isolate as A. terreus. Oral therapy with itraconazole provided complete resolution
of aspergilloma in the patient and no evidence of infection was detected in the mycological and
pathological inspection of BAL samples after 3 months follow-up.
Conclusion:
In conclusion, it is recommended to apply molecular biology techniques for rapid, reliable and
accurate identification of fungal pathogens as well as for selecting effective antifungal therapy.
Kewords:
Aspergillus terreus, Aspergilloma, RBP2

Abstract Number: 83

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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