Aspergillus species is a frequent finding in the sputum of Iranian CF-patients

Ref ID: 19580

Author:

H Badali1*, M Laal Kargar1, S Khalilzadeh2

Author address:

1Invasive Fungi Research Centre (IFRC)/Department of Medical Mycology and Parasitology, School of
Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Pediatric Respiratory Diseases Research Center, NRITLD, Masih Daneshvari Hospital, Sh

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Introduction:
Mutations in CFTR result in a defective mucociliary clearance with production of viscous and
sticky bronchial mucus that facilitates colonization of the airways by various microorganisms which
contribute to the progressive deterioration of lung function. Therefore, considerable attention has
been paid to prevention and control of microbial growth, which has resulted in improvement of
patient management and in a marked increase in the life expectancy of the patient. The objective
of this study was to investigate the frequency of Aspergillus species from respiratory specimens of
Iranian CF patient, including the evaluation of the in vitro susceptibility of the species of antifungal
drugs to improve the antifungal therapy in patients.
Material and Methods:
Forty-two patients diagnosed to have CF, based on positive sweat chloride tests, a characteristic
clinical manifestation, or on mutations in CFTR protein (29 males and 13 females), enrolled in the
Respiratory Research Centre. Aspergillus species identification was performed using conventional
criteria, with confirmation by sequencing of partial beta-tubulin.
Results:
The most frequently isolated filamentous fungi were A. terreus (37.5%), followed by A. fumigatus
and A. oryzae (25%). A higher proportion of patients with persistent Aspergillus colonization had
ABPA than those with no organisms. Finally, male were numerically (but not significantly) more
often persistently colonized with Aspergillus. A. terreus was the predominant species which colonized
in the majority of CF cases that probably due to resistant to antifungal drug like amphotericin B.
Conclusion:
However, in the present study the frequency of Aspergillus species are low, the possibility of fungal
colonization and consideration of their clinical significance in these patients is highly recommended.
Future studies and more factors which may be responsible for the increased isolation of fungi in CF
need to be investigated.
Keywords:
Cystic fibrosis, CFTR gene, fungal colonization, Aspergillus Spp, in vitro antifungal susceptibility

Abstract Number: 105

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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