Aquaporin and aquaglyceroporins in Aspergillus nidulans are dispensable in osmotic stress responses.

Ref ID: 18503


Dong-Soon Oh, Hanyan Lu, Kap-Hoon Han

Author address:

Woosuk University

Full conference title:

11 th European Conference on Fungal Genetics


Aquaporin is a water channel protein found in almost all organisms from bacteria to human. More than 200
members of this family were identified up to date. There are two major categories of Major Intrinsic Protein (MIP)
channels, aquaporins and glycerol facilitators, which facilitate the diffusion across biological membranes of water
or glycerol and other uncharged compounds, respectively. The full genome sequencing of various fungal species
revealed that there are 3 to 5 aquaporins in their genome. However, no functional characteristics were studied so
far in Aspergillus sp. In Aspergillus nidulans, one orthodox aquaporin (aqpA) and four aquaglyceroporins (aqpB~E)
were found in the genome. Knock8208;out of each aquaporin or aquaplyceroporin didn’t show obvious phenotypic
change in osmotic stress, suggesting that the function of the genes may be redundant or not be related in osmotic
stress responses. However, resistance of fluconazol has been changed in some mutants, indicating that the
function of aquaporins play roles in susceptibility of antifungal reagent. [This work was supported by NRF Korea

Abstract Number: PR7.21

Conference Year: 2012

Link to conference website:

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