Antifungal susceptibility and the frequency of Aspergillus fumigatus-related species of clinical strains collected as “A. fumigatus ” from various area in Japan

Ref ID: 19558

Author:

A Watanabe1,2*, K Kikuchi1, Y Oku1, J Ito1, W Tuya1, H Taguchi1, K Yarita1, Y Muraosa1,
M Yahiro1, T Yaguchi1, K Kamei1,2

Author address:

1Division of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan
2Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Purpose:
Azole resistance among clinical isolates of Aspergillus fumigatus is becoming a serious problem in
some countries. In Japan, only a few surveillance reports regarding the antifungal susceptibility of
clinical isolates of A. fumigatus are available, and the nationwide situation remains unkown. The
aim of this study was to determine the present status of azole resistance in A. fumigatus in Japan and
the frequency of A. fumigatus-related species.
Methods:
We employed 178 clinical isolates collected as A. fumigatus from 1987 to 2008 at our institution.
To find A. fumigatus-related species, all isolates were re-examined from morphology and highest
growth temperature, and those with atypical phenotypes were further analyzed genetically. The
antifungal susceptibility of A. fumigatus sensu stricto isolates was tested based on the CLSI M38-A2
broth microdilution method.
Results:
In our collection, 171 isolates were confirmed to be A. fumigatus sensu stricto and the remaining
7 isolates (4.0%) were found to be related species of A. fumigatus, i.e. A. lentulus (2 isolates) and
A. udagawae (5 isolates). Only 1 (0.6%) and 2 isolates (1.2%) showed elevated MIC to voriconazole
and itraconazole, respectively.
Conclusion:
Our study disclosed that the frequency of azole resistance in A. fumigatus still remains low in this
collection.

Abstract Number: 85

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

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