Antifungal Pharmacodynamics: Beyond Candida

Ref ID: 18666

Author:

Nathan P. Wiederhold, PharmD – Associate Professor

Author address:

Univ. of Texas at Austin Coll. of Pharmacy, Univ. of Texas Hlth. Sci. Ctr., San Antonio, TX.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

The pharmacodynamics antifungal agents against Candida species and the pharmacokinetic/pharmacodynamic parameters associated with efficacy in the treatment of invasive candidiasis have been well characterized. Aspergillus species, especially A. fumigatus, have also been extensively studied, and we have a good understanding of antifungal pharmacodynamics against these opportunistic fungi as well as pharmacokinetic/pharmacodynamic targets for the treatment of invasive aspergillosis. Although the pharmacodynamics of many antifungal agents are similar between Aspergillus and Candida species, our understanding is quite limited for other fungi and cannot be extrapolated to these important pathogens, including the causative agents of mucormycosis, Fusarium and Scedosporium species, and endemic fungi. While genomic information is beginning to provide important insights in this area, further studies are needed in order to characterize and fully understand antifungal pharmacodynamics against these other fungi.

Abstract Number: 412

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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