Antifungal Drug Discovery Through the Study of Invertebrate Model Hosts

Ref ID: 18728

Author:

Eleftherios Mylonakis, MD, PhD – Associate Professor

Author address:

Harvard Med. Sch., Mass. Gen. Hosp., Boston, MA.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Antifungal drug discovery is particularly challenging. Virulence-related genes in a variety of fungal pathogens have also been shown to play a role in killing of invertebrate hosts. The model nematode Caenorhabditis elegans as well as insects such as Drosophila melanogaster and Galleria mellonella can be used to study fungal pathogenesis as well as novel antifungal compounds. Especially the C. elegans assay is performed in liquid media using standard 96- or 384-well plate technology. In addition to identifying compounds that inhibit growth, this in vivo whole animal assay also identifies compounds that affect virulence, as well as compounds that modulate evolutionarily preserved host responses. HTS that are based on the use of invertebrate model hosts permit data-driven decisions, eliminate preconceived biases about certain chemical classes or motifs, examine compound characteristics (such as water solubility, stability and toxicity) and avoid inefficiencies associated with the sequential optimization hits.

Abstract Number: 1868

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster