Antifungal activity of nanoparticles of zinc, copper, cerium oxide, silver, gold and selenium against clinical isolates of Aspergillus

Author:

SH Moghadam1*, B Azari2, H Zarrinfar3, M Darroudi4

Author address:

1Student Research Committee, Mashhad University of Medical Sciences, Mashhad , Iran

2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

3Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Full conference title:

10th Advances Against Aspergillosis and Mucormycosis

Date: 2 February 2022

Abstract:

Background:

Aspergillus species found as a saprophyte agent to cause a wide variety of infections in normal to immunocompromised hosts. Its spores easily contaminate the hospital ventilation systems due to their ubiquitous characteristic. Regarding the drug resistance against Aspergillus species, new aspects of using extracts and nanoparticles as antifungal agents were considerable in the past few years.

 

Material and Method:

The antifungal activity of zinc, copper, cerium oxide, silver, gold, and selenium nanoparticles were studied against a total of 11 clinical Aspergillus isolates, including A. fumigatus (n=3), A. flavus (n=4), and A. welwitschiae (n= 4) based on the M38-A2 guideline.

 

Result:

It showed significant minimum inhibitory concentration (MIC) in nanoparticles of zinc, silver, gold, and selenium. Unfortunately, copper and cerium oxide didn’t show inhibitory effect against Aspergillus isolates. The inhibitory ranges of zinc, silver, gold, and selenium nanoparticles respectively were 128-512, 26-53, 21-85, 6-26 µg⁄ml for A. fumigatus and 512, 26-53, 85, 1-13 µg⁄ml for A. welwitschiae. In addition, the inhibitory ranges of silver and selenium nanoparticles were 26-53 and 106-425 µg⁄ml for A. flavus, respectively. The zinc and gold nanoparticles didn’t affect against A. flavus.

 

Conclusion:

All of the nanoparticles studied in this paper, appeared to be effective against Aspergillus isolates except the copper and cerium oxide. Among the tested nanoparticles, antifungal activity was highly noticeable in zinc, silver, gold, and selenium. However, silver seemed to be the most effective nanoparticle against the Aspergillus species.

 

Keywords:

Antifungal; Nanoparticles; Aspergillus; MIC

Abstract Number: 63

Conference Year: 2022

Link to conference website: https://aaam2022.org/

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