Antifungal Activity of Arasertaconazole Nitrate against Fluconazole-Resistant strains

Ref ID: 18737

Author:

N. Marti, PhD – Drug Development Project Leader1, A. Gomez-Lopez, PhD – Researcher 2, D. Gargallo-Viola, PhD – Infectious Diseases Manager 1, A. Guglietta, PhD – R&D Director 1, M. Cuenca-Estrella, PhD – Head of the Spanish National Center for Microb

Author address:

1Res. and Dev. Ctr.. Ferrer Internacional SA, Barcelona, Spain, 2Instituto Carlos III, Madrid, Spain.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Arasertaconazole nitrate is a new antifungal compound for a topical use that has demonstrated a strong in vitro activity against clinically relevant fungal species. In addition to the relevant in vitro activity against yeasts, dermatophytes and opportunistic fungi, arasertaconazole nitrate shows also a moderate anti-inflammatory activity that has the potential to provide clinical benefit in addition to fungus eradication. The clinical development for the Vulvovaginal Candidiasis indication is currently underway. Methods: A total of 299 fluconazole-susceptible (FLC-S) and resistant (FLC-R) Candida spp. clinical isolates were analyzed. Analysis was done according to EUCAST and CLSI FLC breakpoints (susceptible MIC < 2 mg/L, resistant > 4 mg/L). A total of 97 C. albicans (52 FLC-R and 45 FLC-R), 50 C. glabrata (9 FLC-R and 41 FLC-R), 50 C. parapsilosis (44 FLC-R and 6 FLC-R), C. tropicalis (44 FLC-R and 6 FLC-R), and 52 C. krusei were tested. EUCAST reference procedure (document 7.1) was used. C. parapsilosis ATCC 22019 and C. krusei ATCC 6258 were included as quality control strains. Results: Results are showed in the table: MIC in mg/L, GM: Geometric mean, MIC50: MIC for 50% of isolates, MIC90: MIC for 90% of isolates, ND: Not done
Conclusions: Arasertaconazole nitrate showed a very potent activity in vitro against both FLU-S and FLU-R Candida isolates. Arasertaconazole was particularly active against C. glabrata strains with MIC values < 0.06 mg/L.

Abstract Number: M-1718

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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