Ref ID: 18730
Author:
T. F. F. Magalhães, MS – Fellow/ Research Assistant, D. L. da Silva, MS – Fellow/ Research Assistant, C. M. da Silva, MS – Fellow/ Research Assistant, C. V. B. Martins, PhD – Fellow/ Research Assistant, L. J. Nogueira, PhD – Fellow/ Research Assistan
Author address:
Univ.e Federal de Minas Gerais, Belo Horizonte, Brazil.
Full conference title:
52nd Annual ICAAC
Date: 9 September 2014
Abstract:
Background: Cryptococcosis is an invasive mycosis with worldwide occurrence. Cryptococcus neoformans and C. gattii are the main etiologic agents and affect both immunocompromised and immunocompetent patients. Although there are a few effective antifungal agents, the treatment of cryptococcosis is still a problem due to the drugs toxicity and the emergence of resistant strains. Methods: In previous studies the aryl aldimines 2-(benzilideneamine)phenol and 4-(benzilideneamine)phenol has presented good results against C. neoformans. A total of eleven aldimines derived from 2-aminophenol were tested in vitro against 12 strains of C. neoformans and 12 strains of C. gattii. The compounds were evaluated for minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The most active were also tested for activity in combination with amphotericin B, and their effects on the metabolism of preformed biofilms of C. neoformans. Results: All tested aldimines were active against the fungi studied, especially the compounds 3D5 and 3D7, which exhibited the lowest MIC (2-4 µg/mL). Therefore 3D5 and 3D7 were more effective than fluconazole. Conclusions: Considering the results obtained in this study the tested aldimines may be considered promising antifungal agents.
Abstract Number: F-823a
Conference Year: 2012
Link to conference website: NULL
New link: NULL
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